Yes.  SimpleSync can sync to/from Exchange 2007.

SimpleSync does not rely on the RUS. SimpleSync writes to AD, creating/updating your user or contact objects. Default mappings include proxyaddresses (smtp/x400) required to create mail enabled objects.  Default mappings also sync all other required attributes. You may use custom map files to create/modify attribute mappings as desired.  Many SimpleSync users have already migrated and are syncing successfully to Exchange 2007.

The following customizations have been found to be required for most implementations when syncing to Exchange 2007.    These are customizations you can make to the attribute mapping, so the sync can automatically set mailnickname, ShowInAddressbook and LegacyExchangeDN automatically at sync time.

The next release of SimpleSync (date TBD) will include the mappings and functionality to make these customizations obsolete. But for v4.8, they should be applied. See the below links for details and contact Support if you have any questions.

Note 1:
If you are running v4.7 or prior release, see the Syncs to Exchange 2007 set invalid value for mailnickname article for details on the custom mailnickname mapping that is required to sync to Ex2007. As of v4.8, the default mappings have been adjusted to support the new mailnickname requirement (the @ character is not allowed).

Note 2:
If  your synced objects do not show up in the GAL, it may be necessary to use a custom mapping to set the a custom ShowInAddressBook on your synced contacts.

Note 3:
If your synced objects show up in the GAL, but delivery to the recipient fails, it may be necessary to set a custom legacyexchangedn on your synced contacts.